Basic Information
VIS ID
TVIS10017474
Fusion event
HBV-LINC00486 integration
Validated
No
Detection method
TS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26867494
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
DQ089769.1
Region type
X protein;Polymerase;
Start
1472
Integrated sequence
CATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTCTACGTCCCGTCGGCGCTGAATCCCGCGGACGACCCGTCTCGGGGCCG| |TTTGGGACTCTACCGTCCCCTTCTTCGTCTGCCGTTCCGGCCGACCACGGGGCGCACCTCTCTTTACGCGGTCTCCCCGTCTGTGCCTTCTCATCTGCCG
Host Sequence
Chromosome
chr2
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
33141634/32916567 (Hg38)
End
33141634/32916567 (Hg38)
Location type
ncRNA
Target gene
LINC00486
Nearest miRNA
hsa-mir-1301/Upstream/281236; hsa-mir-10b/Downstream/501949;
Nearest TSS
ENST00000437798/Upstream/33766; ENST00000440786/Downstream/10560;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/288364, chr2-CpG: 164/Downstream/29814
Upstream sequence
gccatgcctgTTCTAGATCATTCTGCTAGCTCTTTGACAAAAGTAGTAATAGCCTTTGTTAATTCCTCCAGATAAAAGCAAGTATCTTTTACTAGATTGT
Downstream sequence
gggggggggggggcgggggcggggggggggagggggggggggggggggggggggggggNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
Reference
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.
Curate