VISDB Viral Integration Site DataBase

VIS ID

TVIS10017486

Fusion event

HBV-PPARGC1A integration

Validated

No

Detection method

TS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

HBV

Subtype

C

Reference genome

Region type

X protein;

Start

1724

Integrated sequence

CGCCCGACAGGTCTTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTGTATTT| |AAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTGGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTT

Chromosome

chr4

Cytoband

p15.2

Reference genome

Start

End

23879149/23877526 (Hg38)

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-23a-3p ; hsa-mir-335-5p ; hsa-mir-98-5p ; hsa-mir-421 ; hsa-mir-425-3p ; hsa-mir-378a-5p ; hsa-let-7b-5p ; hsa-mir-130b-3p ; hsa-mir-1277-5p ; hsa-mir-6083 ; hsa-mir-190a-3p ; hsa-mir-4775 ; hsa-mir-3124-3p ; hsa-mir-5011-5p ; hsa-mir-32-3p ; hsa-mir-5585-3p ; hsa-mir-3941 ; hsa-mir-8064 ; hsa-mir-4789-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-485-3p ; hsa-mir-485-5p ; hsa-mir-130a-3p ; hsa-mir-4311 ; hsa-mir-4524a-3p ; hsa-mir-4524b-3p ; hsa-mir-4668-5p

Nearest miRNA

hsa-mir-12113/Upstream/1362141; hsa-mir-1243/Downstream/642666;

Nearest TSS

Nearest CpG islands

None/Target, chr4-CpG: 46/Upstream/1361101, chr4-CpG: 266/Downstream/592551

Upstream sequence

AACAGGTTTTGGGTCCAATAACCTGTATTCAATGATTTCTTCCTTTAAATTGTCTCTAGTATTTACCTCTCGCTCACCATCCCAACCAGTTGGGCTCCTA

Downstream sequence

gactccatctcaaaaaaaaaaaaaaaaaaaaaaaaaaaGTTAAAAGGAACCTGAGAGGTTAAGAAGAAGAAAAAAAAATGGCCCTTACTGAAATTGTTTT