MAN1A1 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017491
Fusion event
HBV-MAN1A1 integration
Validated
No
Detection method
TS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26867494
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
DQ089769.1
Region type
Polymerase;
Start
1193
Integrated sequence
CTTTCTCGCCAACTTACAAGGCCTTTCTGTGTAAACAATATCTGAACCTTTACCCCGTTGCTCGGCAACGGTCAGGTCTTTGCCAAGTATTTGCTGACGC| |AACCCCCACTGGTTGGGGCTTGGCCATAGGCCATCAGCGCATGCGTGGAACCTTTGTGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCAGCTTGT
Host Sequence
Chromosome
chr6
Cytoband
q22.31
Reference genome
GRCh37/hg19
Start
119558649/119237484 (Hg38)
End
119558649/119237484 (Hg38)
Location type
Intronic
Target gene
MAN1A1
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-10398/Upstream/168341; hsa-mir-1202/Downstream/777695;
Nearest TSS
ENST00000381078/Upstream/88097; ENST00000282561/Downstream/112277;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/158426, chr6-CpG: 202/Downstream/110940
Upstream sequence
CCGCAGCGGGCGGCGGGCTTCGTGCGGGAACCTGCTGCAGCCCCCTTGGTCTCTCTCCATCCTCCTCCCTTCCCCCGTcccccccccccggggcccccgc
Downstream sequence
GTCAGTCAGTAATACTTCCTCCTTTTTTGCTTTTTGGTTTTGTCTTGCGTTTCTTTTCTTCTcctctccctctccctctccctctcTGGCTAAGGTCTAA
Reference
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.
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