Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017495
Fusion event
HBV-OTC integration
Validated
No
Detection method
TS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
Region type
core protein;X protein;
Start
1822
Integrated sequence
TTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTGGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTT| |TTTCACCTCTGCCTAATCATCTCATGTTCATGTCCCACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAG
Host Sequence
Chromosome
chrX
Cytoband
p11.4
Reference genome
Start
End
38260948/38401695 (Hg38)
Location type
Intronic
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-23c/Upstream/377709; hsa-let-7f-2/Downstream/1259521;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/73938, chrX-CpG: 19/Downstream/160317
Upstream sequence
gctgaggcaggagaattgcttggatccaggagacagaggttgcagtgagccgacagggtgccattgcaccccagcctgggtgacagagtgagactccgtc
Downstream sequence
GCCATATTTAACACAATGAATGAATAGAGAACACTGGAGCATACAAAATGGACAAGCCATATGTGATTCTATAGACATCAGGTCTGTGGCTTGGGAGTGA
Reference
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.