Basic Information
VIS ID
TVIS10017497
Fusion event
HBV-chr10 integration
Validated
No
Detection method
TS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26867494
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
DQ089769.1
Region type
X protein;
Start
1795
Integrated sequence
TTGAGGCATACTTCAAAGACTGTGTATTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTGGGAGGCTGTAGGCATAAATT| |GGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCCACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTT
Host Sequence
Chromosome
chr10
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
101770227/100010470 (Hg38)
End
101770227/100010470 (Hg38)
Location type
upstream
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Nearest miRNA
hsa-mir-107/Upstream/1085902; hsa-mir-1307/Downstream/964515;
Nearest TSS
ENST00000439456/Upstream/551; ENST00000443919/Downstream/54924;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/229, chr10-CpG: 18/Downstream/54734
Nearby gene
DNMBP(+) ;
Upstream sequence
tggaatggaatagtcaatgaactcgaatggaatcatcattgaatggaatagaatggaatcatcgagtggaatcgaatggaatcacaatcaaatggcatcg
Downstream sequence
TCCACATATCAGCttttttttttttttttttttttttttactttgagttctgggatacatgtgctgaacgtgcaggtttgttacataggtatacatgtgc
Reference
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.
Curate