Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017502
Fusion event
HBV-CHN2 integration
Validated
No
Detection method
TS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
Region type
core protein;X protein;
Start
1824
Integrated sequence
AAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTGGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTT| |TCACCTCTGCCTAATCATCTCATGTTCATGTCCCACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAA
Host Sequence
Chromosome
chr7
Cytoband
p14.3
Reference genome
Start
End
29354570/29314954 (Hg38)
Location type
Intronic
Target gene
Nearest miRNA
hsa-mir-1183/Upstream/2145391; hsa-mir-10399/Downstream/365780;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/119524, chr7-CpG: 17/Downstream/248539
Upstream sequence
GTGGAGGCTGGGTTAGTTCTGGGCTAGAGGGATAGAGTGGCTGCAGGTGGAACCCGGGGGGCCGGGCAGGATGCGAACTTGGTGGGGAAGGAGGGTTTCC
Downstream sequence
AGTGCCACCAAATCCCTCAGAACTAATTACACTGTAAAATATCAGCATCCTCAATGTAGAAGAGTTAACCTTACTGTAATTTAGTATTCAATTATGAAAA
Reference
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.