VISDB Viral Integration Site DataBase

VIS ID

TVIS10017504

Fusion event

HBV-APOC3 integration

Validated

No

Detection method

TS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

HBV

Subtype

C

Reference genome

Region type

pre-S1/pre-S2/S;Polymerase;

Start

344

Integrated sequence

AGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAGCACCCACGTGTCCTGGCCAAAATTTGCAGTCCCCAACCTCCAATCACTCACCAACCT| |CTTGTCCTCCAATTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCT

Chromosome

chr11

Cytoband

q23.3

Reference genome

Start

End

116703541/116832825 (Hg38)

Location type

Exonic

Fragile sites / regions

FRA11G ; FRA11B

Target gene

miRNAs that regulate target gene

hsa-mir-7703 ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-6729-5p ; hsa-mir-4649-5p ; hsa-mir-661 ; hsa-mir-4696 ; hsa-mir-4486 ; hsa-mir-4793-3p ; hsa-mir-766-3p ; hsa-mir-4267 ; hsa-mir-939-3p ; hsa-mir-6849-3p ; hsa-mir-451b ; hsa-mir-508-5p ; hsa-mir-4432 ; hsa-mir-6818-3p ; hsa-mir-548s ; hsa-mir-6864-3p ; hsa-mir-3672 ; hsa-mir-4684-5p ; hsa-mir-593-3p ; hsa-mir-6895-3p ; hsa-mir-3926 ; hsa-mir-769-5p ; hsa-mir-4786-5p ; hsa-mir-3190-5p ; hsa-mir-5699-3p ; hsa-mir-4421 ; hsa-mir-339-5p ; hsa-mir-3613-3p ; hsa-mir-10b-5p ; hsa-mir-10a-5p ; hsa-mir-34a-3p ; hsa-mir-6732-3p ; hsa-mir-5583-3p ; hsa-mir-548c-3p ; hsa-mir-4271 ; hsa-mir-1273g-3p ; hsa-mir-4252

Nearest miRNA

hsa-mir-10392/Upstream/3382737; hsa-let-7a-2/Downstream/1811175;

Nearest TSS

Nearest CpG islands

None/Target, chr11-CpG: 30/Upstream/11181, chr11-CpG: 48/Downstream/2940

Upstream sequence

AAATCAACGGATTTTCTAGACACTATGTAGAGAAAATACCACATGACAACATTTCCCatttataattttaaaattataGAATTCTATGGGCAgccgggca

Downstream sequence

cagtggctcacacctgtaatcccagtactttgggaggctgaggaggccaggtcacttgaggtcaagagttcgaaaccaccctggccaacatggcgaaacc