Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017518
Fusion event
HBV-DTNA integration
Validated
No
Detection method
TS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
Region type
core protein;X protein;
Start
1819
Integrated sequence
TATTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTGGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAA| |CTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCCACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATA
Host Sequence
Chromosome
chr18
Cytoband
q12.1
Reference genome
Start
End
32442248/34862284 (Hg38)
Location type
Intronic
Fragile sites / regions
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-1-2/Upstream/4563324; hsa-mir-122/Downstream/729453;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/367877, chr18-CpG: 19/Downstream/114406
Upstream sequence
gctaatagttgttGATTTATAGCTTAAAATTAATTGTGTGATGCAAATAGGAGGGTTACCACCCCAAGCTTAAATGGAAGTTTTGCAGCACTTTGCACTC
Downstream sequence
TCTCATCCTCTGGATTCAGAAAAGAAGCAATTTTAAAGGAAATTGAAAGAAAGATTGCTTCAAGAGTAAGCAGTCCTTACTCTTGTAAGGATTGCTTGTA
Reference
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.