PLTP _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017527
Fusion event
HBV-PLTP integration
Validated
No
Detection method
TS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26867494
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
DQ089769.1
Region type
X protein;
Start
1690
Integrated sequence
TCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCGACAGGTCTTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGAC| |CGACCTTGAGGCATACTTCAAAGACTGTGTATTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTGGGAGGCTGTAGGCAT
Host Sequence
Chromosome
chr20
Cytoband
q13.12
Reference genome
GRCh37/hg19
Start
44533705/45905066 (Hg38)
End
44533705/45905066 (Hg38)
Location type
Exonic
Target gene
PLTP
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-103a-2/Upstream/199886; hsa-mir-1-1/Downstream/1261901;
Nearest TSS
ENST00000382410/Upstream/7440; ENST00000616084/Downstream/5871;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/13344, chr20-CpG: 44/Downstream/6740
Upstream sequence
gcgccactgcactccagcctgagcagcagagcaaggctctttctcaaaaaaaaaaaaaaaaaaaGTTAAAATTCAAATGGTTCTGAAGAGCTGATcaacc
Downstream sequence
CTGCCCGGTTGGGGAGGCTCCAGTTCCTCTCAGTCAGGGGGAAGAAGGCCCCCTGGGGTGGGGCATTCACAGTCAGGGTCAAGGCAGACTGGCCTGGCAC
Reference
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.
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