MECOM _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017534
Fusion event
HBV-MECOM integration
Validated
No
Detection method
TS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26867494
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
DQ089769.1
Region type
core protein;X protein;
Start
1822
Integrated sequence
TTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTGGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTT| |TTTCACCTCTGCCTAATCATCTCATGTTCATGTCCCACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAG
Host Sequence
Chromosome
chr3
Cytoband
q26.2
Reference genome
GRCh37/hg19
Start
169009246/169291458 (Hg38)
End
169009246/169291458 (Hg38)
Location type
Intronic
Target gene
MECOM
miRNAs that regulate target gene
hsa-mir-22-3p
Nearest miRNA
hsa-let-7g/Upstream/739509; hsa-mir-1224/Downstream/1131645;
Nearest TSS
ENST00000440867/Upstream/22220; ENST00000480669/Downstream/156409;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/141833, chr3-CpG: 122/Downstream/370191
Nearest cancer related gene
MECOM(OG, No orient, 0)
Upstream sequence
TTATCATTCTTTACAATGGCAAAGATTTTGTCGATGCTCCCAGACTGGTCCAGAAAGAAAAGATAGACTGAATTTGTATTTGTGGAAAGCGGCTTGGCTT
Downstream sequence
AATTTCTCCTTTACCTCAGCCTACTTCAGAAATGCTCAATCCTCTCTGTCAGTGTGGGAGATCAGTTTATATTTAGGAGAAGTGGGCAAATGTCTGGTAT
Reference
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.
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