VISDB Viral Integration Site DataBase

VIS ID

TVIS10017537

Fusion event

HBV-TGFBI integration

Validated

No

Detection method

TS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

HBV

Subtype

C

Reference genome

Region type

X protein;Polymerase;

Start

1522

Integrated sequence

GTCTACGTCCCGTCGGCGCTGAATCCCGCGGACGACCCGTCTCGGGGCCGTTTGGGACTCTACCGTCCCCTTCTTCGTCTGCCGTTCCGGCCGACCACGG| |GGCGCACCTCTCTTTACGCGGTCTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTG

Chromosome

chr5

Cytoband

q31.1

Reference genome

Start

End

135396961/136061272 (Hg38)

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-21-5p ; hsa-mir-9-5p ; hsa-mir-30a-5p ; hsa-mir-26b-5p ; hsa-mir-16-5p ; hsa-mir-675-5p ; hsa-mir-6070 ; hsa-mir-7977 ; hsa-mir-5195-3p ; hsa-mir-145-5p ; hsa-mir-6787-3p ; hsa-mir-4267 ; hsa-mir-5690 ; hsa-mir-5588-3p ; hsa-mir-6854-5p ; hsa-mir-629-3p ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-3925-3p ; hsa-mir-766-3p ; hsa-mir-1322 ; hsa-mir-580-5p

Nearest miRNA

hsa-mir-10397/Upstream/258197; hsa-mir-103a-1/Downstream/1586300;

Nearest TSS

Nearest CpG islands

None/Target, chr5-CpG: 87/Upstream/31925, chr5-CpG: 18/Downstream/18108

Nearest cancer related gene

TGFBI(TSG, No orient, 0)

Upstream sequence

TTTCTGTAGTTTGAATATATGCTATTGCACATATCCAACAAAAGTCTTGAATCTTAAAACATACCTTGTTTTCTGAATCATGTGTTGTGGTATGGGTCCT

Downstream sequence

CAGTGCAGTTGAACCTCAGTCCTGCCTCTCCTCATGTGTGCATTCACCTTTCTTGGTGCTCTCTCCCCATGGGCCAAGTTCTACCATGAGTTATGAAACA