TCP11 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017540
Fusion event
HBV-TCP11 integration
Validated
No
Detection method
TS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26867494
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
DQ089769.1
Region type
X protein;
Start
1805
Integrated sequence
CTTCAAAGACTGTGTATTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTGGGAGGCTGTAGGCATAAATTGGTCTGTTCA| |CCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCCACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGA
Host Sequence
Chromosome
chr6
Cytoband
p21.31
Reference genome
GRCh37/hg19
Start
35097287/35129510 (Hg38)
End
35097287/35129510 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA6H
Target gene
TCP11
miRNAs that regulate target gene
hsa-mir-122-5p
Nearest miRNA
hsa-mir-1236/Upstream/888774; hsa-mir-10398/Downstream/340998;
Nearest TSS
ENST00000381078/Upstream/8465; ENST00000274938/Downstream/11517;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/239623, chr6-CpG: 75/Downstream/11514
Upstream sequence
TCCCTATGACATATACAGTGTATCTTTTAAATTTAAAGGATTTATTAAAGTGAAAATCATTGTAGGATACTGTTTGAAACCTGGCTTTACCTTCTAATGG
Downstream sequence
TGTATACACATAGCATTGAGCTAAATGATCTTTCATTTTCTTATACTCCTGAAATCTAGGAAAGGATATTGCTTCTTTGAAAATACCAAAGGTCCacaga
Reference
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.
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