Basic Information
VIS ID
TVIS10017541
Fusion event
HBV-ADGRB3 integration
Validated
No
Detection method
TS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26867494
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
DQ089769.1
Region type
X protein;
Start
1801
Integrated sequence
CATACTTCAAAGACTGTGTATTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTGGGAGGCTGTAGGCATAAATTGGTCTG| |TTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCCACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCA
Host Sequence
Chromosome
chr6
Cytoband
q12
Reference genome
GRCh37/hg19
Start
69364909/68655017 (Hg38)
End
69364909/68655017 (Hg38)
Location type
Intronic
Target gene
ADGRB3
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-10398/Upstream/11264805; hsa-mir-10524/Downstream/2721943;
Nearest TSS
ENST00000381078/Upstream/16341; ENST00000604969/Downstream/577389;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/19863, chr6-CpG: 53/Downstream/1141383
Upstream sequence
GAGAATCAAAATATTCTTAGAATATATGATAATGCCTTCAATAAATATCACTGAAGGACATCATTTAAAAGCAAATTTTATGCAACACTGTTCTCTGGGC
Downstream sequence
GGAAGTCACATATATTATGTATTAATAAATTAACAGTCTCACATTCTCTTTGATCATTGATTGTTTCTTGGCAGTTTGTTACATACTAGATTCTACACAT
Reference
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.
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