VISDB Viral Integration Site DataBase

VIS ID

TVIS10017543

Fusion event

HBV-KANK1 integration

Validated

No

Detection method

TS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

HBV

Subtype

C

Reference genome

Region type

pre-S1/pre-S2/S;Polymerase;

Start

584

Integrated sequence

CCAGGAACATCAACTACCAGCACGGGACCATGCAAGACCTGCACGATTCCTGCTCAAGGAACCTCTATGTTTCCCTCGTGTTGCTGTACAAAACCTTCGG| |ACGGAAATTGCACTTGTATTCCCATCCCATCATCTTGGGCTTTCGCAAGATTCCTATGGGAGTGGGCCTCAGTCCGTTTCTCCTGGCTCAGTTTACTAGT

Chromosome

chr9

Cytoband

p24.3

Reference genome

Start

End

740834/740834 (Hg38)

Location type

Exonic

Target gene

miRNAs that regulate target gene

hsa-mir-124-3p ; hsa-mir-335-5p ; hsa-mir-10a-5p ; hsa-mir-100-5p ; hsa-mir-374b-3p ; hsa-mir-4524b-5p ; hsa-mir-4524a-5p ; hsa-mir-633 ; hsa-mir-3622b-5p ; hsa-mir-873-5p ; hsa-mir-3677-5p ; hsa-mir-646 ; hsa-mir-195-5p ; hsa-mir-424-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-497-5p ; hsa-mir-6838-5p ; hsa-mir-503-5p ; hsa-mir-15a-5p

Nearest miRNA

hsa-mir-1302-9/Upstream/710553; hsa-let-7a-1/Downstream/4109463;

Nearest TSS

Nearest CpG islands

None/Target, chr9-CpG: 64/Upstream/33414, chr9-CpG: 16/Downstream/85748

Nearest cancer related gene

KANK1(TSG, No orient, 0)

Upstream sequence

ATCTAGAACTATTAGCTATCCTTTATTCAGTTCCAGATTGCCTTCATAATAATCATTTGAAAATTACCTTGGTGATCTCATGTTCATGTCCTTTGAACCT

Downstream sequence

ttagcaaaacttgaaaggtatttgtgatactggctgggcgaggtggctcttgcctgtaatcccagcactttaggaagccaaggcaggcagatgacctgag