Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017545
Fusion event
HBV-EIF2S3 integration
Validated
No
Detection method
TS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
Region type
X protein;Polymerase;
Start
1408
Integrated sequence
TCTGGGGCGAAACTGCTCGGCACCGACAACTCTGTTGTCCTCTCTCGGAAATACACCTCCTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGC| |GCGGGACGTCCTTTGTCTACGTCCCGTCGGCGCTGAATCCCGCGGACGACCCGTCTCGGGGCCGTTTGGGACTCTACCGTCCCCTTCTTCGTCTGCCGTT
Host Sequence
Chromosome
chrX
Cytoband
p22.11
Reference genome
Start
End
24094043/24075926 (Hg38)
Location type
Intronic
Target gene
miRNAs that regulate target gene
hsa-mir-7-5p ; hsa-mir-98-5p ; hsa-mir-24-3p ; hsa-mir-331-3p ; hsa-mir-30c-5p ; hsa-mir-196a-5p ; hsa-mir-92a-3p ; hsa-mir-3613-3p ; hsa-mir-212-3p ; hsa-mir-132-3p ; hsa-mir-374a-5p ; hsa-mir-16-1-3p ; hsa-mir-144-3p ; hsa-mir-944 ; hsa-mir-5002-5p ; hsa-mir-6508-5p ; hsa-mir-8067 ; hsa-mir-218-5p ; hsa-mir-579-3p ; hsa-mir-4777-3p ; hsa-mir-4446-5p ; hsa-mir-542-3p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-888-5p ; hsa-mir-758-3p ; hsa-mir-7977 ; hsa-mir-1294 ; hsa-mir-4316 ; hsa-mir-4284 ; hsa-mir-6809-5p ; hsa-mir-6089 ; hsa-mir-5008-5p ; hsa-mir-383-3p ; hsa-mir-4761-5p ; hsa-mir-6865-5p ; hsa-mir-6815-5p ; hsa-mir-665 ; hsa-mir-3678-3p ; hsa-mir-1273h-3p ; hsa-mir-6885-5p ; hsa-mir-328-5p ; hsa-mir-486-3p ; hsa-mir-7160-5p ; hsa-mir-4722-5p ; hsa-mir-2467-3p ; hsa-mir-6086 ; hsa-mir-377-5p ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-1827 ; hsa-mir-4649-3p ; hsa-mir-4532 ; hsa-mir-4257 ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-187-5p ; hsa-mir-221-3p ; hsa-mir-222-3p ; hsa-mir-3120-3p ; hsa-mir-323b-5p ; hsa-mir-3688-5p ; hsa-mir-3689a-5p ; hsa-mir-3689b-5p ; hsa-mir-3689e ; hsa-mir-3689f ; hsa-mir-410-5p ; hsa-mir-4276 ; hsa-mir-4470 ; hsa-mir-4474-3p ; hsa-mir-494-5p ; hsa-mir-511-3p ; hsa-mir-5190 ; hsa-mir-545-3p ; hsa-mir-548v ; hsa-mir-6867-5p ; hsa-mir-7108-5p ; hsa-mir-891a-3p ; hsa-mir-561-3p ; hsa-mir-5696 ; hsa-mir-664b-3p ; hsa-mir-6715b-3p
Nearest miRNA
hsa-mir-23c/Upstream/4058739; hsa-let-7f-2/Downstream/4419629;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/20908, chrX-CpG: 166/Downstream/73259
Upstream sequence
ggtggtctggttgggatccctgcttcccaaagggcccccctatcagctttcagtagaagtccttggtggggcacaggggtggcgagtgccaagttccata
Downstream sequence
ctcctggcctcaagccatcctcccacctcagcctctcaaagtgttgggattacagacatgagccaccccgcccagccCTGTTTCCTTTATTAAGGCTTCC
Reference
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.