VISDB Viral Integration Site DataBase

VIS ID

TVIS10017560

Fusion event

HBV-TMTC2 integration

Validated

No

Detection method

TS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

HBV

Subtype

C

Reference genome

Region type

pre-S1/pre-S2/S;Polymerase;

Start

150

Integrated sequence

ATTTTCCTGCTGGTGGCTCCAGTTCCGGAACAGTAAACCCTGTTCCGACTACTGCCTCTCCCATATCGTCAATCTTCTCGAGGACTGGGGACCCTGCACC| |GAATATGGAGAGCACCACATCAGGATTCCTAGGACCCCTGCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCACAGAGTCTA

Chromosome

chr12

Cytoband

q21.31

Reference genome

Start

End

83460801/83067022 (Hg38)

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-124-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-4470 ; hsa-mir-561-3p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-623 ; hsa-mir-6734-3p ; hsa-mir-6832-3p ; hsa-mir-6770-5p ; hsa-mir-1253 ; hsa-mir-6761-5p ; hsa-mir-4329 ; hsa-mir-4251

Nearest miRNA

hsa-let-7i/Upstream/1908561; hsa-mir-1178/Downstream/3678046;

Nearest TSS

Nearest CpG islands

None/Target, chr12-CpG: 104/Upstream/379155, chr12-CpG: 17/Downstream/1844399

Upstream sequence

AGTTAGAAAAGGGTACAGCCCAGGCTGCCGGGCCGGGCTGGGTCGCGGGGTCCGGGTTCCGCTCCCCATCTCACCCCGCCCTCACCCTAAATCCCAGCAT

Downstream sequence

AGCAAATATATGCCAGGGCATGTGTGTCCAAAGGAGAAAGAAGAATGGGAAAATGTAATCATGGGGAAGAAGGGTAATAGACCCAGGTAGAAAGTGGACT