Fusion event
HBV-FN1 integration
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Region type
core protein;X protein;
Integrated sequence
TTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTGGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACT| |TTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCCACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAA
End
216295137/215430414 (Hg38)
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-10b/Upstream/1672255; hsa-mir-1244-1/Downstream/2470099;
Upstream sequence
TTGGAAATGTGAGATGGCTGTGGTGCATTCCACTGGATGGGGTGGGAGTTGGGCTGACTCGGAGTCTCAGTGATAAATACTTCGACAGGACCACTTGAGC
Downstream sequence
CCTGTGAATGTGCCCTATTTAAATTTCAAACATAGAAGGAAACCTAAACCTTTTGTTCAACTCTATGTCAGTGGCAGTGAGCTGAGATTGAACCTTATCA
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.