Basic Information
VIS ID
TVIS10017579
Fusion event
HBV-ZFHX4-AS1 integration
Validated
No
Detection method
TS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26867494
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
DQ089769.1
Region type
X protein;
Start
1768
Integrated sequence
GACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTGTATTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTT| |TGTACTGGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCCACTGTTCAAG
Host Sequence
Chromosome
chr8
Cytoband
q21.13
Reference genome
GRCh37/hg19
Start
77580377/76668142 (Hg38)
End
77580377/76668142 (Hg38)
Location type
ncRNA
Target gene
ZFHX4-AS1
Nearest miRNA
hsa-mir-124-1/Upstream/1962395; hsa-mir-10400/Downstream/298626;
Nearest TSS
ENST00000518652/Upstream/51701; ENST00000523885/Downstream/13077;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/1259953, chr8-CpG: 59/Downstream/13878
Upstream sequence
AGAACATACTATATTAACCAAAGCCTAAAATAAGACTGGTGTCCTGTAGGGAGCAGCCATTGGTGAATTATACAGGTACCATATTGTACCTTTGCTTTTT
Downstream sequence
TTTAAAAGCAATATTGAATTCTATGAGATTGTCCTTTCTAGAAGTGTAAACTTAATGTATGCAAAGTAAATacacacacacacacacacacacacacaca
Reference
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.
Curate