UBE2M _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017591
Fusion event
HBV-UBE2M integration
Validated
No
Detection method
TS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26867494
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
DQ089769.1
Region type
pre-S1/pre-S2/S;Polymerase;
Start
287
Integrated sequence
CTGCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCACAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAG| |CACCCACGTGTCCTGGCCAAAATTTGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAATTTGTCCTGGTTATCGCTGGATGTGTCTGCG
Host Sequence
Chromosome
chr19
Cytoband
q13.43
Reference genome
GRCh37/hg19
Start
59069834/58558467 (Hg38)
End
59069834/58558467 (Hg38)
Location type
5UTR
Fragile sites / regions
FRA19A
Target gene
UBE2M
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-93-5p
Nearest miRNA
hsa-let-7e/Upstream/8091;
Nearest TSS
ENST00000633603/Upstream/1318; ENST00000593642/Downstream/487;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/3172, chr19-CpG: 115/Downstream/99
Upstream sequence
GCGGGCCCAGGCCTGGGGCGAGCGGCTGCGCGCGCGGATGGAGGAGATGGGCAGCCGGACCCGCGACCGCCTGGACGAGGTGAAGGAGCAGGTGGCGGAG
Downstream sequence
tcctcggacccgcagctgcggcctcctccgctgctgccgccacccgcccggcctgccgcgccgctccgctcctctccgcgcccaccgcgcggcccgcctc
Reference
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.
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