VISDB Viral Integration Site DataBase

VIS ID

TVIS10017592

Fusion event

HBV-EPAS1 integration

Validated

No

Detection method

TS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

HBV

Subtype

C

Reference genome

Region type

X protein;Polymerase;

Start

1566

Integrated sequence

GGGCCGTTTGGGACTCTACCGTCCCCTTCTTCGTCTGCCGTTCCGGCCGACCACGGGGCGCACCTCTCTTTACGCGGTCTCCCCGTCTGTGCCTTCTCAT| |CTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCGACAGGTCTTGCCCAAGGTCTTACATAAGAGGACTCT

Chromosome

chr2

Cytoband

p21

Reference genome

Start

End

46540192/46313053 (Hg38)

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-185-5p ; hsa-mir-145-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-6763-3p ; hsa-mir-4758-3p ; hsa-mir-7108-3p

Nearest miRNA

hsa-mir-1301/Upstream/10841567; hsa-mir-10b/Downstream/1064622;

Nearest TSS

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/13052, chr2-CpG: 23/Downstream/167416

Nearest cancer related gene

EPAS1(TSG, No orient, 0)

Upstream sequence

GCTTCTCAAGTCAGCTAAGTCAGACAGAACTGCAGAGATAGAAGTAGAAGGGAACTCAGATTCTTCCTCAGCTAGGGTAGAATCCTTGGAACAGTGGAGG

Downstream sequence

TTGCCCAAGGTCTTTAAGAGGTCAGACAGCTACTAGCAGAGAAACAGAGCGAATGTTGACACCTAAAAGATACCTTGTCCTTCCGGTGTTactagaagtg