Basic Information
VIS ID
TVIS10017601
Fusion event
HBV-ADGRG6 integration
Validated
No
Detection method
TS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26867494
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
DQ089769.1
Region type
pre-S1/pre-S2/S;Polymerase;
Start
385
Integrated sequence
AGCACCCACGTGTCCTGGCCAAAATTTGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAATTTGTCCTGGTTATCGCTGGATGTGTCTG| |CGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTACCAAGGTATGTTGCCCGTTTGTCCTCTACTTC
Host Sequence
Chromosome
chr6
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
142703147/142382010 (Hg38)
End
142703147/142382010 (Hg38)
Location type
Exonic
Target gene
ADGRG6
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-26b-5p ; hsa-mir-99a-5p
Nearest miRNA
hsa-mir-10398/Upstream/1698127; hsa-mir-1202/Downstream/8720665;
Nearest TSS
ENST00000381078/Upstream/79384; ENST00000508295/Downstream/8302;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/79694, chr6-CpG: 60/Downstream/544662
Upstream sequence
AGCCCATGTGGGAGCTCCTTAAAGGGCCACTCCAGTGGTCATCCTCTCCTCCCGCAATAACCACACACCTGTACTATGTGTAACTTTGGCAACAGGTTGC
Downstream sequence
TCTGTCAAGGTAGGGAGCCCACACCGTGCTCTGGAATCTCTTTGCTTTCTACTTGCAATTTTGGGTAATGTGGTTGTCATTGTTTTGATTTGTATCTGAA
Reference
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.
Curate