CYP3A4 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017602
Fusion event
HBV-CYP3A4 integration
Validated
No
Detection method
TS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26867494
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
DQ089769.1
Region type
core protein;
Start
1860
Integrated sequence
AAGGTCTTTGTACTGGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCCAC| |TGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGCTTCTGTGGAGTTACTCTCTTTTTTGCCT
Host Sequence
Chromosome
chr7
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
99361609/99763986 (Hg38)
End
99361609/99763986 (Hg38)
Location type
Exonic
Fragile sites / regions
FRA7F
Target gene
CYP3A4
miRNAs that regulate target gene
hsa-mir-27b-3p
Nearest miRNA
hsa-mir-10525/Upstream/354722; hsa-mir-10399/Downstream/329574;
Nearest TSS
ENST00000635602/Upstream/28790; ENST00000608397/Downstream/2557;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/146724, chr7-CpG: 76/Downstream/154993
Upstream sequence
CACTGAGAAATGTTTAATTCCTGGGAAGCGTCTTTGATATATGGTCAGTTTCTTCATGTAAATGTCCAAAAACCAATACTGTTTCCTGTTTGTTACATTT
Downstream sequence
TTGGGCCACGAGCTCCAGATCGGACAGAGCTGAAAGGAGAGGAAAGACATTTTAGGTAAATCAGATCAATGTAGGGCATCACAGTTTAGATGAAGAGAAA
Reference
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.
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