VISDB Viral Integration Site DataBase

VIS ID

TVIS10017614

Fusion event

HBV-ITGB3 integration

Validated

No

Detection method

TS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

HBV

Subtype

C

Reference genome

Region type

X protein;Polymerase;

Start

1403

Integrated sequence

GCCGGTCTGGGGCGAAACTGCTCGGCACCGACAACTCTGTTGTCCTCTCTCGGAAATACACCTCCTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGAT| |CCTGCGCGGGACGTCCTTTGTCTACGTCCCGTCGGCGCTGAATCCCGCGGACGACCCGTCTCGGGGCCGTTTGGGACTCTACCGTCCCCTTCTTCGTCTG

Chromosome

chr17

Cytoband

q21.32

Reference genome

Start

End

45363733/47286367 (Hg38)

Location type

Exonic

Target gene

miRNAs that regulate target gene

hsa-let-7a-5p ; hsa-mir-204-5p ; hsa-mir-30c-5p ; hsa-mir-98-5p ; hsa-let-7c-5p ; hsa-mir-320a ; hsa-mir-124-3p ; hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-450a-1-3p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-7977 ; hsa-mir-486-3p ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-449b-5p ; hsa-mir-449a ; hsa-mir-34c-5p ; hsa-mir-34a-5p ; hsa-mir-6089 ; hsa-mir-5693 ; hsa-mir-383-3p ; hsa-mir-17-3p ; hsa-mir-30a-5p ; hsa-mir-192-5p ; hsa-mir-338-3p

Nearest miRNA

hsa-mir-1180/Upstream/313267; hsa-mir-10226/Downstream/746515;

Nearest TSS

Nearest CpG islands

None/Target, chr17-CpG: 26/Upstream/31967, chr17-CpG: 64/Downstream/37141

Nearest cancer related gene

ITGB3(TSG, No orient, 0)

Upstream sequence

agacttgaatgtgtggttgctttatagtgtcaatggtctatgtacttaagtgtgtttttgtgatggccagtaatgtctttcctgtccctgtttaacattc

Downstream sequence

ccgagatgccccagagggtggctttgatgccaTCATGCAGGCTACAGTCTGTGATGTGAGTTTGGAGGACTTGGAGTGCCAGGTGTGGCTGGCATAGATC