VISDB Viral Integration Site DataBase

VIS ID

TVIS10017636

Fusion event

HBV-PPP2R2A integration

Validated

No

Detection method

TS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

HBV

Subtype

C

Reference genome

Region type

pre-S1/pre-S2/S;Polymerase;

Start

315

Integrated sequence

TGTTGACAAGAATCCTCACAATACCACAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAGCACCCACGTGTCCTGGCCAAAATTTGCA| |GTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAATTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTG

Chromosome

chr8

Cytoband

p21.2

Reference genome

Start

End

26217723/26360207 (Hg38)

Location type

Exonic

Target gene

miRNAs that regulate target gene

hsa-mir-31-5p ; hsa-mir-222-3p ; hsa-mir-155-5p ; hsa-mir-1-3p ; hsa-mir-30a-5p ; hsa-mir-26b-5p ; hsa-mir-92a-3p ; hsa-let-7b-5p ; hsa-let-7a-5p ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-409-3p ; hsa-mir-551b-5p ; hsa-mir-605-3p ; hsa-mir-3910 ; hsa-mir-4796-3p ; hsa-let-7c-5p ; hsa-let-7d-5p ; hsa-let-7e-5p ; hsa-let-7f-5p ; hsa-mir-98-5p ; hsa-let-7g-5p ; hsa-let-7i-5p ; hsa-mir-4458 ; hsa-mir-4500 ; hsa-mir-218-5p ; hsa-mir-187-5p ; hsa-mir-154-5p ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa ; hsa-mir-3605-5p ; hsa-mir-3679-5p ; hsa-mir-1185-5p ; hsa-mir-4719 ; hsa-mir-4801 ; hsa-mir-4731-3p ; hsa-mir-101-3p ; hsa-mir-144-3p ; hsa-mir-3202 ; hsa-mir-4533 ; hsa-mir-556-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-1249-5p ; hsa-mir-1343-5p ; hsa-mir-143-3p ; hsa-mir-221-3p ; hsa-mir-3179 ; hsa-mir-363-5p ; hsa-mir-4274 ; hsa-mir-4459 ; hsa-mir-455-3p ; hsa-mir-4695-5p ; hsa-mir-4770 ; hsa-mir-5197-3p ; hsa-mir-548ao-3p ; hsa-mir-548v ; hsa-mir-555 ; hsa-mir-6081 ; hsa-mir-6088 ; hsa-mir-6515-5p ; hsa-mir-665 ; hsa-mir-6745 ; hsa-mir-6797-5p ; hsa-mir-6805-5p ; hsa-mir-6809-5p ; hsa-mir-6864-5p ; hsa-mir-6880-5p ; hsa-mir-7515 ; hsa-mir-766-5p ; hsa-mir-7847-3p ; hsa-mir-939-5p

Nearest miRNA

hsa-mir-124-1/Upstream/1014733; hsa-mir-10400/Downstream/688646;

Nearest TSS

Nearest CpG islands

None/Target, chr8-CpG: 109/Upstream/169626, chr8-CpG: 103/Downstream/22567

Upstream sequence

TGAAAGTGAAGGAGGAAGTACTTTTACCTTGCTTTGTCTGAGCAGTATAAAGCAAATAAAAGCAAGAGTTTTCTTATGGTTATACATACAAAATGAACCA

Downstream sequence

AAAGACCAGAAGGGTATAACTTGAAAGAGGAGGATGGAAGGTATAGAGATCCTACTACAGTTACTACACTACGAGTAAGTACATAAGAAAAAAATGTCAC