VISDB Viral Integration Site DataBase

VIS ID

TVIS10017640

Fusion event

HBV-DNMT1 integration

Validated

No

Detection method

TS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

HBV

Subtype

B

Reference genome

Region type

pre-S1/pre-S2/S;Polymerase;

Start

110

Integrated sequence

TTCCACCAAGCTCTGCTAGATCCCAGAGTGAGGGGCCTATATTTTCCTGCTGGTGGCTCCAGTTCCGGAACAGTAAACCCTGTTCCGACTACTGCCTCTC| |CCATATCGTCAATCTTCTCGAGGACTGGGGACCCTGCACCGAATATGGAGAGCACCACATCAGGATTCCTAGGACCCCTGCTCGTGTTACAGGCGGGGTT

Chromosome

chr19

Cytoband

p13.2

Reference genome

Start

End

10260349/10149673 (Hg38)

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-148a-3p ; hsa-mir-29b-3p ; hsa-mir-152-3p ; hsa-mir-301b-3p ; hsa-mir-126-3p ; hsa-mir-342-3p ; hsa-mir-185-5p ; hsa-mir-140-5p ; hsa-mir-193b-3p ; hsa-mir-148b-3p ; hsa-mir-155-5p ; hsa-mir-877-3p ; hsa-mir-484 ; hsa-mir-149-5p ; hsa-mir-30b-5p ; hsa-mir-100-5p ; hsa-mir-26a-5p ; hsa-mir-1260b ; hsa-mir-200a-3p ; hsa-mir-200b-3p ; hsa-mir-429 ; hsa-mir-29a-3p ; hsa-mir-92a-3p ; hsa-mir-20a-5p ; hsa-mir-19b-3p ; hsa-mir-19a-3p ; hsa-mir-18a-5p ; hsa-mir-17-5p ; hsa-let-7c-5p ; hsa-mir-218-5p ; hsa-mir-30a-5p ; hsa-mir-30c-5p ; hsa-mir-217 ; hsa-mir-1264 ; hsa-mir-377-3p ; hsa-mir-1343-3p ; hsa-mir-548q ; hsa-mir-6782-5p ; hsa-mir-6783-3p

Nearest miRNA

hsa-mir-1227/Upstream/111260; hsa-let-7e/Downstream/80740;

Nearest TSS

Nearest CpG islands

None/Target, chr19-CpG: 112/Upstream/7432, chr19-CpG: 89/Downstream/44617

Nearest cancer related gene

DNMT1(TSG, No orient, 0)

Upstream sequence

CGAGCCCCTGGTGGAAGACATGCAGCGCCAGTGGGCCGGGCTGGTGGAGAAGGTGCAGGCTGCCGTGGGCACCAGCGCCGCCCCTGTGCCCAGCGACAAT

Downstream sequence

GGCATGGGGAGAAAGTTCTGACTTGGCCAGCAGATATGTGACCAAGTCTATGCAGGAGCACTCGTCCTTTTCAGTTTTCATCTAGGGCAAAAAGCTGCTG