Fusion event
HBV-SACM1L integration
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Region type
core protein;X protein;
Integrated sequence
ACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTGGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCAC| |CTCTGCCTAATCATCTCATGTTCATGTCCCACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTG
End
45785190/45743698 (Hg38)
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-12127/Upstream/881717; hsa-let-7g/Downstream/2105857;
Upstream sequence
AAGGTAGAAATCTTATAAGCTTTACAACTCTGAAAACATACCTTAACTGTCACAGCAACTAATTCAAAACAAACAAAAAATTCTGCTAAAACCAACAAAG
Downstream sequence
GGAAGATTCCATTGTGCAGAACTGGAGTCTTTACTGACCCGCTTTCCACATCAGCCCAAGGTCTTTTTAATGCCTTTATCCAAAAGCACATCTTGTGCTC
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.