GRIA4 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017650
Fusion event
HBV-GRIA4 integration
Validated
No
Detection method
TS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26867494
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
DQ089769.1
Region type
core protein;X protein;
Start
1827
Integrated sequence
GACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTGGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCA| |CCTCTGCCTAATCATCTCATGTTCATGTCCCACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTT
Host Sequence
Chromosome
chr11
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
105508559/105637832 (Hg38)
End
105508559/105637832 (Hg38)
Location type
Intronic
Target gene
GRIA4
miRNAs that regulate target gene
hsa-mir-484
Nearest miRNA
hsa-mir-10392/Upstream/1787852; hsa-let-7a-2/Downstream/5709925;
Nearest TSS
ENST00000527297/Upstream/26834; ENST00000527687/Downstream/204951;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/27137, chr11-CpG: 26/Downstream/384166
Upstream sequence
CTCATGCCCTGCTCTGTTGCTTCCCCTGACTGATTTAGGGGCTGGGTGACCGATGGCTTCAGTTCCCTGAAAGACTACTGGAGCACCGTTAAGGACAAGT
Downstream sequence
TCTCTGAGTTCTGGGATTTGGACCCTGAGGTCAGACCAACTTCAGCCGTGGCTGCCTGAGACCTCAATACCCCAAGTCCACCTGCCTATCCATCCTGCGA
Reference
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.
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