Basic Information
VIS ID
TVIS10017651
Fusion event
HBV-LOC643339 integration
Validated
No
Detection method
TS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26867494
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
DQ089769.1
Region type
core protein;X protein;
Start
1826
Integrated sequence
AGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTGGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCATGTTCATGTCCCACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATT
Host Sequence
Chromosome
chr12
Cytoband
q22
Reference genome
GRCh37/hg19
Start
93619638/93225862 (Hg38)
End
93619638/93225862 (Hg38)
Location type
ncRNA
Target gene
LOC643339
Nearest miRNA
hsa-let-7i/Upstream/6480713; hsa-mir-1178/Downstream/1335927;
Nearest TSS
ENST00000382841/Upstream/10183; ENST00000550056/Downstream/151846;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/296140, chr12-CpG: 85/Downstream/151827
Upstream sequence
CAATTATCTTGATCTTTTTCTCACATACTGTATTTACTCATTAGTTCAAAAATAGTTTTTAAGCTTTTACAATGTAAATTAGGGGACAAGAATTGGTATG
Downstream sequence
ATACTACCTGCTTCTGAGGTACTTATCTAGTAAAAAGTGGAGTTGTTGATAAAAACATAAATAGGATAAAACACATTAAATGCTAAGTGAACAAACCCTT
Reference
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.
Curate