VISDB Viral Integration Site DataBase

VIS ID

TVIS10017653

Fusion event

HBV-MAP2K1 integration

Validated

No

Detection method

TS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

HBV

Subtype

B

Reference genome

Region type

core protein;

Start

1879

Integrated sequence

GCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCCACTGTTCAAGCCTCCAAGCTG| |TGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGCTTCTGTGGAGTTACTCTCTTTTTTGCCTTCTGACTTCTTTCCTTCTA

Chromosome

chr15

Cytoband

q22.31

Reference genome

Start

End

66687371/66395033 (Hg38)

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-424-5p ; hsa-mir-34a-5p ; hsa-mir-1826 ; hsa-mir-497-5p ; hsa-mir-128-3p ; hsa-mir-181a-5p ; hsa-mir-101-3p ; hsa-mir-93-3p ; hsa-mir-30c-5p ; hsa-mir-142-5p ; hsa-mir-559 ; hsa-mir-548b-5p ; hsa-mir-548a-5p ; hsa-mir-548c-5p ; hsa-mir-548d-5p ; hsa-mir-548j-5p ; hsa-mir-548k ; hsa-mir-548l ; hsa-mir-548h-5p ; hsa-mir-548i ; hsa-mir-548w ; hsa-mir-548y ; hsa-mir-548o-5p ; hsa-mir-548ab ; hsa-mir-548ad-5p ; hsa-mir-548ae-5p ; hsa-mir-548ak ; hsa-mir-548am-5p ; hsa-mir-451b ; hsa-mir-548ap-5p ; hsa-mir-548aq-5p ; hsa-mir-548ar-5p ; hsa-mir-548as-5p ; hsa-mir-548au-5p ; hsa-mir-5590-3p ; hsa-mir-548av-5p ; hsa-mir-548ay-5p ; hsa-mir-6507-5p ; hsa-mir-8054 ; hsa-mir-548bb-5p ; hsa-mir-624-5p ; hsa-mir-181b-5p ; hsa-mir-494-3p ; hsa-mir-34c-5p ; hsa-mir-34b-3p ; hsa-mir-449a ; hsa-mir-448 ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-889-3p ; hsa-mir-6856-5p ; hsa-mir-6758-5p

Nearest miRNA

hsa-mir-10393/Upstream/354701; hsa-mir-11181/Downstream/101925;

Nearest TSS

Nearest CpG islands

None/Target, chr15-CpG: 55/Upstream/7408, chr15-CpG: 32/Downstream/102562

Upstream sequence

aaactttaaaatgcctcagcatcacttgggagcttattgaaatgcagatcccagagtcagtaaatctgcctgtgaagtatgatagtctgcatttgtaatg

Downstream sequence

ACTTATTTATGCACCTTTCAAAGAAAGGAAGAAGATACTGTGGTAGAGTAcagtagtcctcccttatctgagtggcatatgttccaagacccctagtgga