PRSS53 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017654
Fusion event
HBV-PRSS53 integration
Validated
No
Detection method
TS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26867494
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
DQ089769.1
Region type
X protein;
Start
1804
Integrated sequence
ACTTCAAAGACTGTGTATTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTGGGAGGCTGTAGGCATAAATTGGTCTGTTC| |ACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCCACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGG
Host Sequence
Chromosome
chr16
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
31096525/31085204 (Hg38)
End
31096525/31085204 (Hg38)
Location type
Exonic
Target gene
PRSS53
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-1225/Upstream/191219; hsa-mir-11401/Downstream/3078374;
Nearest TSS
ENST00000527434/Upstream/9302; ENST00000561755/Downstream/3524;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/4729, chr16-CpG: 84/Downstream/8926
Upstream sequence
GGGGTGCAGCCCATACTGAATGAACACACCTTCTGTGCTGGCATGTCTAAGTACCAAGAAGACACCTGCTATGGCGATGCGGGCAGTGCCTTTGCCGTTC
Downstream sequence
GGGCCATGGGGAGGGTGCTCCTGCCTGGGGACCTGCTGTCCTCAAGGATCCACAGGCTGAAACAGATAAGTGCCTCATCTGACTTCTtgctaagcacttc
Reference
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.
Curate