Basic Information
VIS ID
TVIS10017656
Fusion event
HBV-MIR548W integration
Validated
No
Detection method
TS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26867494
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
DQ089769.1
Region type
core protein;X protein;
Start
1832
Integrated sequence
GGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTGGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCT| |GCCTAATCATCTCATGTTCATGTCCCACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGC
Host Sequence
Chromosome
chr17
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
61035856/62958495 (Hg38)
End
61035856/62958495 (Hg38)
Location type
ncRNA
Target gene
MIR548W
Nearest miRNA
hsa-mir-10226/Upstream/14183; hsa-mir-1250/Downstream/1542279;
Nearest TSS
ENST00000595228/Upstream/149995; ENST00000581424/Downstream/10054;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/149999, chr17-CpG: 145/Downstream/7469
Upstream sequence
gtgtgccaccacacccagctaatttttgtatttttagtagagacagggtttcaccatgttggccaggctggtctcaaactcctgatctcaggtgatccac
Downstream sequence
ATAGTAATATTTATTAACTACCTTATAACTACTTATGTGCTCTGAGTGAGGGCATATATCAggttcatgaaaacccacacagctattggagaattaactc
Reference
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.
Curate