MAPKAP1 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017669
Fusion event
HBV-MAPKAP1 integration
Validated
No
Detection method
TS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26867494
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
DQ089769.1
Region type
core protein;X protein;
Start
1823
Integrated sequence
TAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTGGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTT| |TTCACCTCTGCCTAATCATCTCATGTTCATGTCCCACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGA
Host Sequence
Chromosome
chr9
Cytoband
q33.3
Reference genome
GRCh37/hg19
Start
128426275/125663996 (Hg38)
End
128426275/125663996 (Hg38)
Location type
Intronic
Target gene
MAPKAP1
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-26b-5p
Nearest miRNA
hsa-let-7a-1/Upstream/970198; hsa-mir-12126/Downstream/2026691;
Nearest TSS
ENST00000422679/Upstream/6286; ENST00000492314/Downstream/5849;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/255123, chr9-CpG: 58/Downstream/42830
Upstream sequence
TTTGTAGTTTGTGTTATGTGTTGTTATTGAACAGCATTAAGTTTTTGCGGGGAATTTTTCTTGATAGAAAATAAAAGTCCTGATTTTTGTCAACAAGAAA
Downstream sequence
GCTGTGAGCCCTCAAAAGACAAGCATGCCCATGGCAATGAATCAGACTGTGGGAGGCCATCTTCAACCACAGTCCAATACGTGAAGCTTTCTTCAACTGC
Reference
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.
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