CYP2E1 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017677
Fusion event
HBV-CYP2E1 integration
Validated
No
Detection method
TS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26867494
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
DQ089769.1
Region type
X protein;Polymerase;
Start
1613
Integrated sequence
CGACCACGGGGCGCACCTCTCTTTACGCGGTCTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAG| |ACCACCGTGAACGCCCGACAGGTCTTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAG
Host Sequence
Chromosome
chr10
Cytoband
q26.3
Reference genome
GRCh37/hg19
Start
135352352/133538848 (Hg38)
End
135352352/133538848 (Hg38)
Location type
Exonic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
CYP2E1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-132-3p ; hsa-mir-488-3p ; hsa-mir-488-5p
Nearest miRNA
hsa-mir-107/Upstream/167185;
Nearest TSS
ENST00000439456/Upstream/1348; ENST00000479535/Downstream/26735;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/9791, chr10-CpG: 84/Downstream/26531
Upstream sequence
gtcataaggatgtggtgctttaatccaccactggttgagaatagaaaatggtaccaccactttggaaaactgccttaccatttcttaaaaggataaacat
Downstream sequence
gcctaccagatgatccagctactccattcctaggtattttacccaagagaaatgaaaacatatgtttatatgaaatcttgctgacaaatgttcactttta
Reference
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.
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