Fusion event
HBV-DLG2 integration
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Region type
core protein;X protein;
Integrated sequence
GGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTGGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCT| |GCCTAATCATCTCATGTTCATGTCCCACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGC
End
83680124/83969081 (Hg38)
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-10392/Upstream/2078245; hsa-let-7a-2/Downstream/2309252;
Upstream sequence
ACTGGATTTTCTGTGGGACAGCTATTAATGCTTAAGGAAAAATAACGTAGAGAACTCTTTCAGTGAACATCAAAAAGCAGGAACACAAGCCAATATAGAC
Downstream sequence
CTTTGAGAACAAAGGTAATTTTCTTTTATATAAATGAGACAATCCAGCTCTCACTCTTCAGAAATAAACAGCAATAGCTATTATTATAAACAGCACGACT
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.