Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017702
Fusion event
HBV-ACOX2 integration
Validated
No
Detection method
TS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
Region type
pre-S1/pre-S2/S;Polymerase;
Start
3018
Integrated sequence
CTTTCCCGGTCACCAGTTGGACCCTGCATTCGGAGCCAATTCAAACAATCCAGATTGGGACTTCAACCCCAACAAGGATCAATGGCCAGCGGCACACCAG| |GTAGGAGTGGGATCCTTCGGGCCAGGGTTCACTCCACCACACGGCAATCTTTTGGGGTGGAGCCCTCAGGCTCAGGGCATATTGACAACAGTACCAGCAG
Host Sequence
Chromosome
chr3
Cytoband
p14.3
Reference genome
Start
End
58493005/58507278 (Hg38)
Location type
Intronic
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-let-7g/Upstream/2654684; hsa-mir-12124/Downstream/2110527;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/14731, chr3-CpG: 47/Downstream/79484
Upstream sequence
gcctcttgtgccaaacagcccagttgtaaatgcaaagggagtattttgaagaaaaataaaagtgctactccattgaactctacaatgagaagaaagtgaa
Downstream sequence
gaagactccttcgttgttcacagtcaagtggaaggagatagaAGTGAATGGGATGAAGTGCATCAATGTTTTCCCAAATGTGTTGACCCTCTGGGTCAGT
Reference
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.