Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017710
Fusion event
HBV-BHMT integration
Validated
No
Detection method
TS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
Region type
X protein;
Start
1756
Integrated sequence
AGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTGTATTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAG| |ATTAAAGGTCTTTGTACTGGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTC
Host Sequence
Chromosome
chr5
Cytoband
q14.1
Reference genome
Start
End
78415208/79119385 (Hg38)
Location type
Intronic
Target gene
Nearest miRNA
hsa-mir-10397/Upstream/6240722; hsa-mir-103a-1/Downstream/3720770;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/49497, chr5-CpG: 193/Downstream/116323
Upstream sequence
TTGTAGTTTAATGTCAAGGAACCAACATGTTACACCAGAAGGGTTGTTTGGGGCTACTAATATTTTCTTAGTTCCACTTCATTAATACTTGTCATGAAGA
Downstream sequence
AACCAGCCGTGGGACTTTTAGAAGGATATTGTCGACCTATTGCATCAACAAAGCTCCCATAGAGAAAAGGGTTCAACCTCTTCAGAGTTTTGTTTTATTT
Reference
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.