VISDB Viral Integration Site DataBase

VIS ID

TVIS10017717

Fusion event

HBV-GTF2I integration

Validated

No

Detection method

TS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

HBV

Subtype

C

Reference genome

Region type

X protein;

Start

1797

Integrated sequence

GAGGCATACTTCAAAGACTGTGTATTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTGGGAGGCTGTAGGCATAAATTGG| |TCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCCACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGG

Chromosome

chr7

Cytoband

q11.23

Reference genome

Start

End

74124741/74710410 (Hg38)

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-let-7b-5p ; hsa-mir-21-5p ; hsa-mir-1229-3p ; hsa-mir-10a-3p ; hsa-mir-484 ; hsa-mir-23b-3p ; hsa-mir-99a-5p ; hsa-let-7e-5p ; hsa-let-7a-5p ; hsa-mir-335-3p ; hsa-mir-1305 ; hsa-mir-607 ; hsa-mir-3671 ; hsa-mir-580-5p ; hsa-mir-1252-3p ; hsa-mir-3646 ; hsa-mir-3121-3p

Nearest miRNA

hsa-mir-10525/Upstream/114384; hsa-mir-10399/Downstream/1204787;

Nearest TSS

Nearest CpG islands

None/Target, chr7-CpG: 39/Upstream/51658, chr7-CpG: 124/Downstream/77579

Upstream sequence

GAAATATtttccctgaggatattaatgtcatgtttcttctacctgcacaaattacttttctgtttattttggactttcctgtgttagatgatgtccttac

Downstream sequence

AACTttttaataacatcgattgcttttgcctattttgaccttcatatgagtggaattacacaacatgtactcttttgtatctggcCACAAAGGTCTGCTT