Basic Information
VIS ID
TVIS10017724
Fusion event
HBV-GNG12-AS1 integration
Validated
No
Detection method
TS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26867494
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
DQ089769.1
Region type
core protein;X protein;
Start
1827
Integrated sequence
GACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTGGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCA| |CCTCTGCCTAATCATCTCATGTTCATGTCCCACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTT
Host Sequence
Chromosome
chr1
Cytoband
p31.3
Reference genome
GRCh37/hg19
Start
68497084/68031401 (Hg38)
End
68497084/68031401 (Hg38)
Location type
ncRNA
Fragile sites / regions
FRA1L
Target gene
GNG12-AS1
Nearest miRNA
hsa-mir-101-1/Upstream/1402884; hsa-mir-11399/Downstream/152117;
Nearest TSS
ENST00000473358/Upstream/75996; ENST00000434072/Downstream/19226;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/197633, chr1-CpG: 30/Downstream/15559
Upstream sequence
AAAGACAGCCGTTGGGGAGAGGACGGTGGCCCCATGGACCACGCCCCATAGCTCACTGTGCATGCCATATATACGGAAGCCCAAGAAGTTGGCCAGCATC
Downstream sequence
CCGACCATTGCGGCCCTCAACTTGTCTTCGGTGTCAAGTTTTGCAGCGACTAGCACCAGCTGGTCCTGTAGGGCCTTTTCATCCACAGGGGATGTCTTGG
Reference
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.
Curate