Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017730
Fusion event
HBV-SERPINF1 integration
Validated
No
Detection method
TS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
Region type
pre-S1/pre-S2/S;Polymerase;
Start
167
Integrated sequence
TCCAGTTCCGGAACAGTAAACCCTGTTCCGACTACTGCCTCTCCCATATCGTCAATCTTCTCGAGGACTGGGGACCCTGCACCGAATATGGAGAGCACCA| |CATCAGGATTCCTAGGACCCCTGCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCACAGAGTCTAGACTCGTGGTGGACTTC
Host Sequence
Chromosome
chr17
Cytoband
p13.3
Reference genome
Start
End
1665797/1762503 (Hg38)
Location type
Intronic
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-22/Upstream/48516; hsa-mir-10226/Downstream/287405;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/8120, chr17-CpG: 75/Downstream/67088
Upstream sequence
AGCAGCAGGGAGTCAAAGGGGAAAAAGTCTTCCAGCCATAGCCTGAGTCATAAAGGGAAGAAACTGAGCAGTGGGAAAGGTGTGAGCAGTTTTAcctccg
Downstream sequence
TGCTTCCACCAAGGGCAGTCAGGAAGGCGGCCGCCCTGCAGCCCAGCCCTGGCCCCTGCTCCCTCGGCTCCCTGCTACTTTTTCAAAATCAGCTGGTGCT
Reference
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.