Basic Information
VIS ID
TVIS10017732
Fusion event
HBV-TMEM220-AS1 integration
Validated
No
Detection method
TS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26867494
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
DQ089769.1
Region type
core protein;
Start
2084
Integrated sequence
GATCTCCTCGACACCGCCTCTGCTCTGTATCGGGAGGCCTTAGAGTCTCCGGAACATTGTTCACCTCACCATACAGCACTAAGGCAAGCTATTCTGTGTT| |GGGGTGAGTTGATGAATCTGGCCACCTGGGTGGGAAGTAATTTGGAAGACCCAGCATCCAGGGAATTAGTAGTAAGCTATGTCAATGTTAATATGGGCCT
Host Sequence
Chromosome
chr17
Cytoband
p13.1
Reference genome
GRCh37/hg19
Start
10666748/10763431 (Hg38)
End
10666748/10763431 (Hg38)
Location type
ncRNA
Fragile sites / regions
FRA17A
Target gene
TMEM220-AS1
Nearest miRNA
hsa-mir-1253/Upstream/2576427; hsa-mir-10226/Downstream/1318468;
Nearest TSS
ENST00000595228/Upstream/33115; ENST00000582334/Downstream/5558;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/33258, chr17-CpG: 244/Downstream/476739
Upstream sequence
CCACCTGCTTGCCCATGTTTGGCTACAAACACGTGCTGACGCTAACTGACCAGGTGACCCGCttcaatgaggaagtgaagaagcagagtgtgtcacggaa
Downstream sequence
agccaccgcacTGAGATCGTtttatatgggccatgccttttctcacattctaaaattcctttcttattctgtcctttcctatcataatatcaaggacatc
Reference
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.
Curate