Basic Information
VIS ID
TVIS10017733
Fusion event
HBV-CCDC178 integration
Validated
No
Detection method
TS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26867494
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
DQ089769.1
Region type
core protein;X protein;
Start
1831
Integrated sequence
GGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTGGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTC| |TGCCTAATCATCTCATGTTCATGTCCCACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAG
Host Sequence
Chromosome
chr18
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
30669694/33089730 (Hg38)
End
30669694/33089730 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA18A
Target gene
CCDC178
Nearest miRNA
hsa-mir-1-2/Upstream/2790770; hsa-mir-122/Downstream/2502007;
Nearest TSS
ENST00000575820/Upstream/135655; ENST00000647014/Downstream/46347;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/317391, chr18-CpG: 45/Downstream/350816
Upstream sequence
tgtttattctagaaaagcagctgaatctcagtaagagcagcaagctttgcggtgctttcacttcctatccacctctcaactgtgaaatccagcagcctca
Downstream sequence
AAACAAATACATGGTGACTTCATCAAAATACCCATGGACtttttttaactttaaagataaaatattaaaaatgacatatttttataaaaaGTATTTGAAA
Reference
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.
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