VISDB Viral Integration Site DataBase

VIS ID

TVIS10017735

Fusion event

HBV-CNOT3 integration

Validated

No

Detection method

TS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

HBV

Subtype

B

Reference genome

Region type

pre-S1/pre-S2/S;Polymerase;

Start

650

Integrated sequence

ATGTTTCCCTCGTGTTGCTGTACAAAACCTTCGGACGGAAATTGCACTTGTATTCCCATCCCATCATCTTGGGCTTTCGCAAGATTCCTATGGGAGTGGG| |CCTCAGTCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTG

Chromosome

chr19

Cytoband

q13.42

Reference genome

Start

End

54647405/54143669 (Hg38)

Location type

Exonic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-185-3p ; hsa-mir-652-3p ; hsa-let-7c-5p

Nearest miRNA

hsa-let-7e/Upstream/161272; hsa-mir-10394/Downstream/138440;

Nearest TSS

Nearest CpG islands

None/Target, chr19-CpG: 112/Upstream/5060, chr19-CpG: 72/Downstream/15696

Nearest cancer related gene

CNOT3(TSG, No orient, 0)

Upstream sequence

GGGCGTGGGTTCCTTGCCGCTGTCTGGGGTAGAGGAGAAGATGTTCAGCCTCCTCAAGAGAGCCAAAGTGCAGCTATTCAAGATCGATCAGCAGCAGCAG

Downstream sequence

ACCAAATCAAGACATGGGTAGCGTCCAACGAGATCAAGGACAAGAGGCAGCTTATAGACAACCGCAAGCTCATTGAGACGGTAGGAGCCCAGAGCCTGAG