Basic Information
VIS ID
TVIS10017754
Fusion event
HBV-LOC105374898 integration
Validated
No
Detection method
TS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26867494
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
DQ089769.1
Region type
X protein;Polymerase;
Start
1582
Integrated sequence
TACCGTCCCCTTCTTCGTCTGCCGTTCCGGCCGACCACGGGGCGCACCTCTCTTTACGCGGTCTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGC| |ACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCGACAGGTCTTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATG
Host Sequence
Chromosome
chr6
Cytoband
p25.1
Reference genome
GRCh37/hg19
Start
5997488/5997255 (Hg38)
End
5997488/5997255 (Hg38)
Location type
downstream
Fragile sites / regions
FRA6B
Target gene
LOC105374898
Nearest miRNA
hsa-mir-3691/Upstream/848933; hsa-mir-10398/Downstream/172049;
Nearest TSS
ENST00000381078/Upstream/145749; ENST00000230568/Downstream/5708;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/74, chr6-CpG: 61/Downstream/1661
Nearby gene
NRN1 ;
Upstream sequence
AAAAATATTCAGAATCTGGTAAAAAAAACTAACTTTAGTTACTTCTAAATTGAAGATTAATTCTAGATGATTTAATAGTCAAACATTTTTGGTTGTtgag
Downstream sequence
AGCTTCCTCCCACAGCCACCTTCTCCAAGAAATCAGATTTCGATTTCTCTGAACCCAGAGACCTGCATGCAGTTCTTTCTCCCCCGCCTACTCCAGGCCT
Reference
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.
Curate