OTC _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017756
Fusion event
HBV-OTC integration
Validated
No
Detection method
TS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26867494
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
DQ089769.1
Region type
pre-S1/pre-S2/S;Polymerase;
Start
404
Integrated sequence
CAAAATTTGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAATTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCC| |TCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTACCAAGGTATGTTGCCCGTTTGTCCTCTACTTCCAGGAACATCAACTACCAG
Host Sequence
Chromosome
chrX
Cytoband
p11.4
Reference genome
GRCh37/hg19
Start
38268182/38408929 (Hg38)
End
38268182/38408929 (Hg38)
Location type
Exonic
Target gene
OTC
miRNAs that regulate target gene
hsa-mir-26b-5p
Nearest miRNA
hsa-mir-23c/Upstream/384943; hsa-let-7f-2/Downstream/1252287;
Nearest TSS
ENST00000429181/Upstream/56324; ENST00000494037/Downstream/152441;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/81172, chrX-CpG: 19/Downstream/153083
Upstream sequence
ctaagtagctaggactattggctcacaccaccgtgatcagctaatttttttgttttttgtagacacttggtctcactgtgttgcccagcatgatctcaaa
Downstream sequence
AATGTATTAATTACAGACACTTGGATAAGCATGGGACAAGAAGAGGAGAAGAAAAAGCGGCTCCAGGCTTTCCAAGGTTACCAGGTTACAATGAAGGTAC
Reference
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.
Curate