PPFIA2 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017764
Fusion event
HBV-PPFIA2 integration
Validated
No
Detection method
TS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26867494
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
DQ089769.1
Region type
pre-S1/pre-S2/S;Polymerase;
Start
142
Integrated sequence
GGGCCTATATTTTCCTGCTGGTGGCTCCAGTTCCGGAACAGTAAACCCTGTTCCGACTACTGCCTCTCCCATATCGTCAATCTTCTCGAGGACTGGGGAC| |CCTGCACCGAATATGGAGAGCACCACATCAGGATTCCTAGGACCCCTGCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCAC
Host Sequence
Chromosome
chr12
Cytoband
q21.31
Reference genome
GRCh37/hg19
Start
82021685/81627906 (Hg38)
End
82021685/81627906 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA12B
Target gene
PPFIA2
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-let-7i/Upstream/469445; hsa-mir-1178/Downstream/5117162;
Nearest TSS
ENST00000382841/Upstream/29535; ENST00000550506/Downstream/48941;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/549566, chr12-CpG: 34/Downstream/130635
Upstream sequence
CAAGGAAggagttagaagaaaggccatagttagggatagagatgtgggagtcatttgcaaaaaggaaatggtaccaaagaattgggtaacatcaacaatg
Downstream sequence
gagggaatatacaaaagagaagagaatcaatttcaggcatttgggaatttctacattttaaatttcgaataaggaaggcagccaagacagtgacagggCA
Reference
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.
Curate