Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017765
Fusion event
HBV-DNMT3L integration
Validated
No
Detection method
TS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
Region type
pre-S1/pre-S2/S;Polymerase;
Start
532
Integrated sequence
CTTGTTGGTTCTTCTGGACTACCAAGGTATGTTGCCCGTTTGTCCTCTACTTCCAGGAACATCAACTACCAGCACGGGACCATGCAAGACCTGCACGATT| |CCTGCTCAAGGAACCTCTATGTTTCCCTCGTGTTGCTGTACAAAACCTTCGGACGGAAATTGCACTTGTATTCCCATCCCATCATCTTGGGCTTTCGCAA
Host Sequence
Chromosome
chr21
Cytoband
q22.3
Reference genome
Start
End
45666394/44246511 (Hg38)
Location type
Exonic
Target gene
Nearest miRNA
hsa-let-7c/Upstream/636522; hsa-mir-6815/Downstream/1231755;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/3222, chr21-CpG: 24/Downstream/11896
Upstream sequence
GAGTTCTGTTGAAAAATACTTGAAATATTCTCTTAGGGGGAGAAAGCAGTTCTTCACCAGCTTGGTGGGCCACTTGGCCGCGAGCTTCGAGCTCTGCTTG
Downstream sequence
TTCTGGGCCAGCAGGGACAATTCTTCTTCCGAAACCAGAGCCCAGTGCCTGCTGCTGAGAGGAGGGGAGGGAAGGTTGTGAGCAAGCGCAGCGCCCACTG
Reference
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.