Basic Information
VIS ID
TVIS10017785
Fusion event
HBV-ASIC1 integration
Validated
No
Detection method
TS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26867494
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
DQ089769.1
Region type
X protein;
Start
1727
Integrated sequence
CCGACAGGTCTTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTGTATTTAAA| |GACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTGGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCA
Host Sequence
Chromosome
chr12
Cytoband
q13.12
Reference genome
GRCh37/hg19
Start
50455526/50061743 (Hg38)
End
50455526/50061743 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA12A
Target gene
ASIC1
miRNAs that regulate target gene
hsa-let-7b-5p
Nearest miRNA
hsa-mir-1244-3/Upstream/1289706; hsa-let-7i/Downstream/172399;
Nearest TSS
ENST00000382841/Upstream/1856; ENST00000549792/Downstream/8997;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/3583, chr12-CpG: 45/Downstream/19343
Upstream sequence
AACCATCTGGTAGAAGTGAGTAGCTCTGCCTTCTAGGCTTTGACTCTGATTGGAGGATGATGGACTTGGGAGCCGTATTTTAATGTCTAAGGAGATGGGG
Downstream sequence
AGGTATAAAGTAGTCACTCTAGGTGTACACAGTACCGCTCCAGGTGTACAGTTTGCACATTGACCTCTAGGTGGCACTAGCATGTTTAGTTAGGACCAAG
Reference
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.
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