Basic Information
VIS ID
TVIS10017798
Fusion event
HBV-SPATA33 integration
Validated
No
Detection method
TS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26867494
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
DQ089769.1
Region type
core protein;X protein;
Start
1817
Integrated sequence
TGTATTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTGGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGC| |AACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCCACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTA
Host Sequence
Chromosome
chr16
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
89734500/89668092 (Hg38)
End
89734500/89668092 (Hg38)
Location type
Intronic
Target gene
SPATA33
Nearest miRNA
hsa-mir-11401/Upstream/951755;
Nearest TSS
ENST00000527434/Upstream/7264; ENST00000615131/Downstream/12645;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/9864, chr16-CpG: 16/Downstream/485
Upstream sequence
GCGTTCCACCAGCACTTCAGGACTCTCCTTCACAGGAGCCTTTCTAGGCCCTTTGGCTCTTGGGACTTCCTCCGGTTCCTCTTCCTTCCTGTTTGGGACA
Downstream sequence
cctgaggtcgggagttcaagaccagcctggccaacatggagaaaccctgtctctactaataatacaaaaattccccaggtgtggtggcaggagcctgtag
Reference
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.
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