VISDB Viral Integration Site DataBase

VIS ID

TVIS10017799

Fusion event

HBV-NEDD4L integration

Validated

No

Detection method

TS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

HBV

Subtype

C

Reference genome

Region type

X protein;

Start

1805

Integrated sequence

CTTCAAAGACTGTGTATTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTGGGAGGCTGTAGGCATAAATTGGTCTGTTCA| |CCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCCACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGA

Chromosome

chr18

Cytoband

q21.31

Reference genome

Start

End

56063299/58396067 (Hg38)

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-24-3p ; hsa-mir-1296-5p ; hsa-mir-423-5p ; hsa-mir-7855-5p ; hsa-mir-6807-5p ; hsa-mir-7843-3p ; hsa-mir-4710 ; hsa-mir-4792 ; hsa-mir-650 ; hsa-mir-3612 ; hsa-mir-2467-3p ; hsa-mir-6086 ; hsa-mir-377-5p ; hsa-mir-1827 ; hsa-mir-4487 ; hsa-mir-558 ; hsa-mir-3160-3p ; hsa-mir-5186 ; hsa-mir-4786-3p ; hsa-mir-665 ; hsa-mir-4459 ; hsa-mir-4257 ; hsa-mir-6511a-5p ; hsa-mir-1910-3p ; hsa-mir-4695-5p ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-6504-3p ; hsa-mir-656-3p ; hsa-mir-5011-5p ; hsa-mir-93-3p ; hsa-mir-30a-5p ; hsa-mir-376c-3p

Nearest miRNA

hsa-mir-1-2/Upstream/2916769; hsa-mir-122/Downstream/55007;

Nearest TSS

Nearest CpG islands

None/Target, chr18-CpG: 67/Upstream/139231, chr18-CpG: 92/Downstream/274912

Nearest cancer related gene

NEDD4L(TSG, No orient, 0)

Upstream sequence

gaggaggaggaggagaggagAGCTGGGCCTGGGGGCTCCATGGACCAGGGCCAGAGAGCCAAGACACAGGTAAGAAAGGACAAAGTGGCCCGTCAGACTG

Downstream sequence

AAGGCTTTTTTATTCTCTTACTCAAACCTCATGCCCTATTAACCAGATCGAGGAAGTGCTGTTGTGGCTTTTCACCTACACTTTTTGTTCCTTTTGCAGC