VISDB Viral Integration Site DataBase

VIS ID

TVIS10017806

Fusion event

HBV-EMX1 integration

Validated

No

Detection method

TS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

HBV

Subtype

C

Reference genome

Region type

core protein;X protein;

Start

1821

Integrated sequence

TTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTGGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACT| |TTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCCACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAA

Chromosome

chr2

Cytoband

p13.2

Reference genome

Start

End

73154484/72927355 (Hg38)

Location type

Intronic

Fragile sites / regions

FRA2S ; FRA2E

Target gene

miRNAs that regulate target gene

hsa-mir-4646-5p ; hsa-mir-6858-5p ; hsa-mir-4689 ; hsa-mir-1224-5p ; hsa-mir-6077 ; hsa-mir-3915 ; hsa-mir-4784 ; hsa-mir-3150b-3p ; hsa-mir-3928-3p ; hsa-mir-6859-5p ; hsa-mir-3916 ; hsa-mir-3125 ; hsa-mir-100-3p ; hsa-mir-2110 ; hsa-mir-6780b-5p ; hsa-mir-4725-3p ; hsa-mir-4271

Nearest miRNA

hsa-mir-1285-2/Upstream/2674350; hsa-mir-10b/Downstream/2163457;

Nearest TSS

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/2424, chr2-CpG: 156/Downstream/143146

Upstream sequence

GCTTCTTGGATATATAGGTGACTCAGTTGTTGTGGCTCCTGCCCAGACACTCTCCAATGCCGAGTTTCAGATGTTGAGACGTACTTCAATCAATGTTGTT

Downstream sequence

ttctgtatctgtgagattgaatgacacaaattccagggttttttctagtgctgagtttctgtgactcCTCTACATTCTACTTCTCTGTGTTTCTGTATAC